Hua-Lin Wu Chair Professor
(Scientific board member of AcaHealth Pharma & Biotech Company)
Academic experience:
1968 – 1972 Bachelor of Science, National Taiwan University, ROC.
1972 – 1974 Master Degree, National Taiwan University, ROC. (Biochemistry)
1976 – 1980 Ph.D, Ohio State University, USA. (Biochemistry)
1980 – 1983 Research Fellow, Northwestern University, USA. (Chemistry)
1983 – 1988 Associate Professor, Department of Biochemistry & Molecular biology, College of Medicine, National Cheng Kung University
1988 – 2010 Professor, Department of Biochemistry & Molecular biology, College of Medicine, National Cheng Kung University
1989 – 1995 Director, Department of Medical Technology, College of Medicine, National Cheng Kung University
1996 – 1999 Director, Department of Biochemistry & Molecular biology, College of Medicine, National Cheng Kung University
2002 ~ Distinguished Professor, Department of Biochemistry & Molecular biology, College of Medicine, National Cheng Kung University
2010 ~ Chair Professor, Department of Biochemistry & Molecular biology, College of Medicine, National Cheng Kung University
Research Interest
Cardiovascular disease is still an important global health problem. Vascular Biology is the major research interest in my lab. Thrombomodulin is a
transmembrane protein in vascular endothelial cells and keratinocytes. It can regulate blood coagulation by activating protein C, which in turn
inhibits blood coagulation by inactivation of factors Va and VIIIa. Thrombomodulin also plays an important role in cell-cell adhesion. It can
regulate the distribution of plasminogen and migration of endothelial cells. Recently we also demonstrated that it can regulate inflammation
responses by association with CD14 and monocyte adhesion to inflammatory endothelial cells. We also interested in the role of thrombomodulin
in wound healing and in vascular diseases including atherosclerosis and aortic aneurysm using tissue specific gene knockout mice and recombinant proteins.
Expertise:
Vascular biology, Haemostasis and fibrinolysis, Biotechnology.